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Blood Sugar Control

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Causes of Hypoglycemia

In people taking certain blood-glucose lowering medications, blood glucose can fall too low for a number of reasons:

  • meals or snacks that are too small, delayed, or skipped
  • excessive doses of insulin or some diabetes medications, including sulfonylureas and meglitinides (Alpha-glucosidase inhibitors, biguanides, and thiazolidinediones alone should not cause hypoglycemia but can when used with other diabetes medicines.)
  • increased activity or exercise
  • excessive drinking of alcohol


Your diabetes treatment plan is designed to match your medication dosage and schedule to your usual meals and activities. If you take insulin but then skip a meal, the insulin will still lower your blood glucose, but it will not find the food it is designed to break down. This mismatch might result in hypoglycemia.

To help prevent hypoglycemia, you should keep in mind several things:

  • Your diabetes medications. Some medications can cause hypoglycemia. Ask your health care provider if yours can. Also, always take medications and insulin in the recommended doses and at the recommended times.
  • What to Ask Your Doctor About Your Diabetes Medications

    • Could my diabetes medication cause hypoglycemia?
    • When should I take my diabetes medication?
    • How much should I take?
    • Should I keep taking my diabetes medication if I am sick?
    • Should I adjust my medication before exercise?

  • Your meal plan. Meet with a registered dietitian and agree on a meal plan that fits your preferences and lifestyle. Do your best to follow this meal plan most of the time. Eat regular meals, have enough food at each meal, and try not to skip meals or snacks.
  • Your daily activity. Talk to your health care team about whether you should have a snack or adjust your medication before sports or exercise. If you know that you will be more active than usual or will be doing something that is not part of your normal routine—shoveling snow, for example—consider having a snack first.
  • Alcoholic beverages. Drinking, especially on an empty stomach, can cause hypoglycemia, even a day or two later. If you drink an alcoholic beverage, always have a snack or meal at the same time.
  • Your diabetes management plan. Intensive diabetes management—keeping your blood glucose as close to the normal range as possible to prevent long-term complications—can increase the risk of hypoglycemia. If your goal is tight control, talk to your health care team about ways to prevent hypoglycemia and how best to treat it if it does occur.

Normal and target blood glucose ranges (mg/dL)

Normal blood glucose levels in people who do not have diabetes
Upon waking (fasting)70 to 110
After meals70 to 140
Target blood glucose levels in people who have diabetes
Before meals90 to 130
1 to 2 hours after the start of a meal less than 180
Hypoglycemia (low blood glucose)70 or below


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