Liver CleansePage 2 of 3
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Diseases that Affect the Liver
Alagille Syndrome - an inherited disorder characterized by a progressive loss of the bile ducts within the liver and narrowing of bile ducts outside the
liver over the first year of life. Symptoms include jaundice, pale, loose stools and poor growth within the first three months of life.
Alpha 1 -
Antitrypsin Deficiency - a hereditary disease that may lead to hepatitis and cirrhosis. It is the most common genetic cause of liver disease in children.
The disease most often appears in the newborn period with jaundice, swelling of the abdomen, and poor feeding. It may also appear in late childhood or adulthood
and be detected because of the appearance of fatigue, poor appetite, swelling of the abdomen and legs or abnormal liver tests.
Hepatitis - a progressive inflammation of the liver associated with an abnormality of the body's immune system and related to the production of
antibodies. Common symptoms include fatigue, abdominal discomfort, aching joints, itching, jaundice, enlarged liver, and spider angiomas (tumors) on
Biliary Atresia - a serious disease of the very young infant. This disease results in inflammation and obstruction of the ducts
which carry bile from the liver into the intestine. Cirrhosis results when healthy liver cells are destroyed, in this case by disease, and replaced
with scar tissue.
Chronic Hepatitis - an ongoing injury to the cells of the liver with inflammation which lasts for longer than six months.
Causes of chronic hepatitis are viruses, metabolic or immunologic abnormalities and medications. Signs and symptoms may include fatigue, mild discomfort
in the upper abdomen, loss of appetite and aching joints.
Cancer of the Liver - The most common primary malignant tumor of the liver is an
hepatocellular carcinoma. Chronic carriers of hepatitis B virus, particularly those with chronic hepatitis or cirrhosis, are at substantially increased
risk of developing hepatocellular carcinoma. Recent research also indicates that patients who have long-standing chronic hepatitis C virus infection
are also at increased risk for the development of
Cirrhosis - a group of chronic liver diseases in which normal liver cells are damaged and replaced by scar tissue,
decreasing the amount of normal liver tissue. Cirrhosis and other liver diseases take the lives of over 25,000 Americans each year and rank eighth as a cause
of death in the United States. There are many causes for cirrhosis. Long-term alcohol abuse is one. Chronic hepatitis is another major cause. In children, the most
frequent causes are biliary atresia, a disease that damages the bile ducts, and neonatal hepatitis. Children with these diseases often receive liver transplants.
Many adult patients who require liver transplants suffer from primary biliary cirrhosis. We do not yet know what causes this illness, but it is not in any way related to
alcohol consumption. Cirrhosis can also be caused by hereditary defects in iron or copper metabolism or prolonged exposure to toxins.
Cystic Disease of the Liver - These include choledochal cysts, Caroli's Syndrome, Congenital Hepatic Fibrosis,
and Polycystic Liver Disease.
Fatty Liver - an accumulation of fat cells in the liver, common in patients who are overweight or who have diabetes.
Galactosemia - a rare hereditary disease caused by elevated levels of galactose (a sugar in milk) in the blood resulting from a deficiency of the
liver enzyme required to break it down. The disease usually appears in the first few days of life following the ingestion of breast milk or formula. Vomiting,
liver enlargement, and jaundice are often the earliest signs of the disease, but bacterial infections, irritability, failure to gain weight, and diarrhea may
Gallstones - this condition, affecting approximately 20 million Americans, can cause severe and intermittent pain in the right upper
abdomen, as well as chronic indigestion and nausea. The removal of the gallbladder due to the formation of gallstones is the most common surgical procedure
performed in the United States.
Gilbert's Syndrome - a relatively common and benign congenital (probably hereditary) liver disorder, found
more frequently in males. It is characterized by a mild, fluctuating increase in serum bilirubin, a yellow pigment excreted by the liver into bile.
Hemochromatosis - a genetic condition that causes the body to absorb and store too much iron. While many individuals with this disease have no symptoms,
injuries to the liver can slowly lead to cirrhosis if the illness is not treated.
Hepatitis A - this inflammation of the liver is usually caused by eating
food or drinking water that has been contaminated with human excrement. Symptoms similar to the flu and fatigue may occur; however, the disease is rarely life
Hepatitis B - one of the most serious forms of hepatitis, this disease is more common and much more infectious than AIDS. Chronic
hepatitis B may lead to scarring of the liver, called cirrhosis, and cancer of the liver. Individuals can protect themselves from hepatitis B with a safe
and effective hepatitis B vaccine. (Click here for more information on the vaccine.)
Hepatitis C - this disease affects approximately 150,000
Americans each year. The most commonly recognized "risk factors" for acquiring hepatitis C virus include use of intravenous drugs, history of blood
transfusions, hemodialysis and health care employment. Transmission may also occur through sexual contact.
Neonatal Hepatitis - inflammation
of the liver that occurs only in early infancy, usually between one and two months after birth. Symptoms include jaundice, failure to grow or gain weight,
and an enlarged liver and spleen.
Porphyria - a disease in which porphyrins, a chemical compound in the body, do not successfully perform
their task of forming heme (the substance that makes blood red) in human beings. When they do not function properly, porphyrins build up in the body,
causing a variety of symptoms ranging from abdominal pain and weakness to blisters on the skin.
Primary Biliary Cirrhosis - a chronic
liver diseases that causes slow, progressive destruction of bile ducts in the liver. The disease is 10 times more frequent in women than men, and is
usually diagnosed in people 30 to 60 years of age. Many patients have no symptoms and are diagnosed through the appearance of an abnormality on routine
liver blood tests.
Primary Sclerosing Cholangitis - a disease in which the bile ducts inside and outside the liver become narrowed due to inflammation and scarring. It usually begins in the
30's, 40's or 50's and is commonly associated with fatigue, itching and jaundice.
Reye's Syndrome - a rare complication of childhood
respiratory infections characterized by vomiting that begins three to seven days after the onset of flu or chickenpox. It is believed that aspirin
may contribute to the development of Reye's Syndrome. Other symptoms include listlessness, staring, and drowsiness.
Sarcoidosis - a
systemic disease of unknown cause, in which nests of cells appear in many tissues, including the lung, lymph nodes and liver. Blacks are affected
about 15 times more often than whites in the United States, with the highest incidence in the southeastern states.
Tyrosinemia - a
genetic inborn error of metabolism associated with severe liver disease in infancy. Children may have either the acute form, in which symptoms appear
in the first month of life, or a more chronic form. In both cases, liver transplantation is required.
Type I Glycogen Storage Disease - a
deficiency of the enzyme glucose - 6 - phosphatase which helps in maintaining a normal blood glucose (sugar concentration) during fasting. Symptoms
include growth failure, a greatly enlarged liver, and a distended abdomen.
Wilson's Disease - An inherited disorder of copper secretion
by the liver. Copper accumulates in the liver and nervous system leading to severe liver and neurological disease. Penicillamine is a successful
treatment for patients with early Wilson's Disease; liver transplantation is indicated for those with very advanced disease.
Preventing and Treating Liver Disease
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